C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques
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چکیده
منابع مشابه
C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques.
BACKGROUND Detection of C4d along peritubular capillaries (PTC) in renal allograft biopsies is an independent prognostic marker of poor long-term graft survival. It is typically associated with circulating donor-specific antibodies. Since only little information is available on the best technique to stain C4d, we compared the two methods most often used for detecting C4d in renal allograft spec...
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BACKGROUND AND OBJECTIVES Diffuse C4d staining in peritubular capillaries (PTCs) during an acute rejection episode (ARE) is the footprint of antibody-mediated rejection. In current clinical practice, diffuse C4d+ staining during acute rejection is regarded as an inferior prognostic sign. This case-control study investigated the prognostic role of mere C4d staining for graft outcome during an AR...
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Immunostaining of renal allograft biopsies for C4d deposition has become an important diagnostic tool in the recognition of humoral-mediated graft rejection. The majority of studies have been performed on frozen tissue sections with one of several commercially available antibody reagents. However, only a single small series that compared reagents or methods, including staining of formalin-fixed...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2006
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfl594